Question asked by: 
Dawn
Date asked: 
Jun 2015

Two and a half years ago I was diagnosed with ovarian clear cell carcinoma Stage 1a.This was a very early diagnosis and just in one ovary. I had surgery to remove my ovaries. After this I opted for three-monthly monitoring instead of hysterectomy or chemotherapy. Since then my CA125 blood levels have been normal and the monitoring has shown all is normal.

Am I right in understanding that now I have passed the two-year landmark the chances of recurrence are much lower? I am half-way now to the five-year target. Is there any new research about clear cell carcinoma at stage 1 that I should know about? I understood at the time that clear cell carcinoma is a particularly aggressive type at later stages but probably not if caught at the earliest stage.

Am I right in understanding that now I have passed the two-year landmark the chances of recurrence are much lower?
Clear cell carcinoma of the ovary is a relatively rare tumour
Response by David Nugent, Consultant gynaecology oncology surgeon

Whilst it would be inappropriate to comment upon individual cases there are some general points which can be made. Clear cell carcinoma of the ovary is a relatively rare tumour, representing approximately 5-10 per cent of epithelial ovarian cancers and in some cases may be associated with a background of previous endometriosis. 

There is evidence that they may behave in a more aggressive manner with less response to standard chemotherapy, with more advanced disease stage 1A tumours represent the earliest stage of the disease. It is reassuring that it is well over two years since the diagnosis and the longer this duration the greater the reassurance that can be gained. 

I’m not aware of any new research on stage 1 clear cell carcinoma of the ovary although in more advanced cases of the disease there have been on-going studies to examine the effectiveness of different chemotherapy regimens compared to the standard carboplatin and paclitaxel.