My relative's stage IV epithelial ovarian cancer has recurred just over 12 months after she was treated with radical surgery, followed by chemotherapy with carboplatin, paclitaxel and bevacizumab. She is BRCA2 positive, and her cancer is oestrogen receptor positive. The recurrent tumours are small - less than 1cm and she is asymptomatic. Instead of repeating her chemotherapy straight away, she has been started on anastrozole to reduce the oestrogen that may be helping the tumours to develop. I have two questions:
1. I am struggling to find the evidence for using anastrozole in epithelial ovarian cancer. I know a trial is underway. How effective is anastrozole as far as we know?
2. If the anastrozole works, will it shrink the tumours, or just prevent them growing further, and can it prevent further tumours forming elsewhere?