Question asked by: 
Cheryl
Date asked: 
Dec 2015

I'm on Everel 50 HRT patches following my removal of my 1c granulosa cell tumour (which ruptured 26 hours prior to removal).  I'm concerned about the safety of being on HRT with history of hormonal cancer. Can you advise?

Is it safe to be on HRT with my history of hormonal cancer?
Speak to the consultant who led the treatment for your granulosa cell tumour before considering any further HRT.
Response by Professor Richard Edmondson, Professor of Gynaecological Oncology

For ovarian cancer in general there is no evidence that taking HRT post treatment is harmful and some evidence even indicates it can be beneficial. However, the results were not broken down by oestrogen sensitivity of the tumours. I am not aware of any studies specifically looking at the risks of taking HRT after treatment for ovarian cancers which may be driven by oestrogen, such as some granulosa tumours. Therefore, I would strongly recommend you have a detailed discussion with the consultant who led the treatment for your granulosa cell tumour before considering any further HRT.