Question asked by: 
Lorraine
Date asked: 
Mar 2015

Why does calcification (the build up of calcium salts in body tissue) occur and what does it mean? A friend and I both have low grade disease and we have a lot of calcification but we don't understand the significance of this. 

Why does calcification (the build up of calcium salts in body tissue) occur and what does it mean?
More research is needed into this.
Response by Professor Iain McNeish, Professor of Gynaecological Oncology

This is a very good question and the honest answer is that I don’t know why it happens. 

The implications of calification are in terms of response in low grade serous disease. There has only been one small study, which suggested that calcification itself was not associated with better or worse prognosis in low grade serous disease, but more research is needed into this.

We did know that this form of calcification is very typical in low grade serous disease but you do also sometimes see it in high grade serous cancers as well.