Key information

Recruitment dates:

14 March, 2016 to 31 December, 2019
(Trial recruitment open)

Treatment stage:

prevention/diagnosis

Trial investigator:

Professor Andrea Rockall, Imperial College Healthcare NHS Trust

Trial website:

Tags:

Ovarian cancer
MRI
CT
mpMRI
imaging
primary peritoneal
fallopian
scan

Acronym:

MROC

Clinical trial locations

Location list

Contact: Prof Iain McNeish
Address:
Glasgow
G12 0YN
Address:
Ipswich
IP4 5PD
Contact: Dr Priya Narayanan
Address:
London
NW1 2BU

Introduction

This trial is for women who have suspected ovarian cancer, or who have been diagnosed but before they’ve had surgery.

Doctors want to see if an mpMRI scan is better than a CT scan in showing who needs an operations and how big the operation should be. They want to see if an mpMRI should either replace or be used as well as a CT scan.

About the trial

Surgery is the usual treatment for ovarian cancer. A CT scan is used to check where the cancer is in the body and helps doctors to know if surgery would be a suitable treatment choice.  However, sometimes the CT scan can’t:

  • tell the difference between disease that is not cancer (benign) and cancer (malignant disease)
  • always show how far the cancer has spread (the stage of the cancer)
  • show when it is best to have an operation

This means that some women have surgery and don’t need it because they don’t have cancer. And some women go for an operation and are then unable to have the cancer removed because it has spread too far.

An mpMRI scan is very similar to an MRI scan but can give doctors extra information about a patient’s disease. Doctors want to see if an mpMRI scan is more effective than a CT scan at showing who needs an operations and how big the operation should be. They want to see if an mpMRI should either replace or be used as well as a CT scan.

The researchers want to see if an mpMRI scan is better than a CT scan before surgery in showing who needs an operation and how big the operation should be. They want to see if an mpMRI scan should either replace or be used as well as a CT scan. 

The trial is recruiting at the following sites:

Hammersmith Hospital

The Royal Marsden Hospital

University College Hospital

Royal Sussex County Hospital

The Beatson Cancer Centre, Glasgow

Kingston Hospital

Liverpool Women's/Clatterbridge Cancer Centre

Norfolk & Norwich Hospital

Royal Surrey County Hospital

Croydon University Hospital

Epsom and St Helier Hospitals

Gloucestershire Hospitals NHS Foundation Trust

Gateshead Health NHS Foundation Trust

Cambridge University Hospitals

London North West University NHS

 

Who can take part?

This study is for women who might have ovarian cancer and some women who have ovarian cancer. The women who have cancer may be having chemotherapy and may go on to have surgery. 

You may be able to join this study if:

  • You have suspected ovarian, fallopian tube or primary peritoneal cancer OR
  • You are having chemotherapy for ovarian, fallopian tube or primary peritoneal cancer and you are due to have surgery for the first time

And the following apply. You:

  • Are fit enough to have surgery 
  • Are at least 18 years old

 

Exclusion criteria

You cannot join this study if any of these apply. You:

  • can’t have an MRI scan for any reason – this could be because you are not able to lie flat, have metal (iron) implants or a pacemaker in your body, or you cannot cope with small spaces (claustrophobic)
  • can’t have a CT scan for any reason such as your kidneys do not work well enough to flush through the contrast medium or you are allergic to the contrast
  • have any serious medical condition or mental health problem that the study team think could affect you taking part
  • are pregnant

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.