Professor Andrea Rockall, Imperial College Healthcare NHS Trust
Clinical trial locations
This trial is for women who have suspected ovarian cancer, or who have been diagnosed but before they’ve had surgery.
Doctors want to see if an mpMRI scan is better than a CT scan in showing who needs an operations and how big the operation should be. They want to see if an mpMRI should either replace or be used as well as a CT scan.
About the trial
Surgery is the usual treatment for ovarian cancer. A CT scan is used to check where the cancer is in the body and helps doctors to know if surgery would be a suitable treatment choice. However, sometimes the CT scan can’t:
- tell the difference between disease that is not cancer (benign) and cancer (malignant disease)
- always show how far the cancer has spread (the stage of the cancer)
- show when it is best to have an operation
This means that some women have surgery and don’t need it because they don’t have cancer. And some women go for an operation and are then unable to have the cancer removed because it has spread too far.
An mpMRI scan is very similar to an MRI scan but can give doctors extra information about a patient’s disease. Doctors want to see if an mpMRI scan is more effective than a CT scan at showing who needs an operations and how big the operation should be. They want to see if an mpMRI should either replace or be used as well as a CT scan.
The researchers want to see if an mpMRI scan is better than a CT scan before surgery in showing who needs an operation and how big the operation should be. They want to see if an mpMRI scan should either replace or be used as well as a CT scan.
The trial is recruiting at the following sites:
The Royal Marsden Hospital
University College Hospital
Royal Sussex County Hospital
The Beatson Cancer Centre, Glasgow
Liverpool Women's/Clatterbridge Cancer Centre
Norfolk & Norwich Hospital
Royal Surrey County Hospital
Croydon University Hospital
Epsom and St Helier Hospitals
Gloucestershire Hospitals NHS Foundation Trust
Gateshead Health NHS Foundation Trust
Cambridge University Hospitals
London North West University NHS
Who can take part?
This study is for women who might have ovarian cancer and some women who have ovarian cancer. The women who have cancer may be having chemotherapy and may go on to have surgery.
You may be able to join this study if:
- You have suspected ovarian, fallopian tube or primary peritoneal cancer OR
- You are having chemotherapy for ovarian, fallopian tube or primary peritoneal cancer and you are due to have surgery for the first time
And the following apply. You:
- Are fit enough to have surgery
- Are at least 18 years old
You cannot join this study if any of these apply. You:
- can’t have an MRI scan for any reason – this could be because you are not able to lie flat, have metal (iron) implants or a pacemaker in your body, or you cannot cope with small spaces (claustrophobic)
- can’t have a CT scan for any reason such as your kidneys do not work well enough to flush through the contrast medium or you are allergic to the contrast
- have any serious medical condition or mental health problem that the study team think could affect you taking part
- are pregnant