Target Ovarian Cancer

The Clinical Trials Information Centre aims to give you information about what clinical trials are taking place that you may be eligible for. The search function below allows you to search by your location, your treatment stage and the stage of the trial. If you find a trial you think you may be eligible for, we suggest you print the information to take along to your next appointment with your clinical team as you will not be able to join the trial without the support of your clinical team.

In addition to the larger trials taking place in centres across the UK, there are sometimes phase I trials which have an even stricter entry criteria. We have not listed all of these but have instead listed where the phase I centres are so that you can ask your clinical team to contact them to find out if there’s any trials you may be eligible for.

This site will be updated regularly as trials are opening and closing in different locations all the time. Whilst we endeavour to keep it as up to date as we can, please always check with your clinical team about the availability of a trial in your area.

If you are confused about some of the terms and language used in the trial descriptions, use our glossary of terms used in clinical trials.

If you have any queries about the clinical trials information centre, you can call the Target Ovarian Cancer support line on 020 7923 5475 or email support@targetovariancancer.org.uk

Results list

ARIEL4: A Study of Rucaparib Versus Chemotherapy in BRCA Positive Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

The aim of the trial is to fully understand the benefits of a PARP inhibitor versus standard chemotherapy for BRCA positive women who have had two previous treatments. It is a three arm trial, where women will be randomised to receive:

CEBOC: Evaluation of the Safety of Cediranib in the Prevention of Bowel Perforation in Platinum-Resistant Ovarian Cancer

The main purpose of the trial is to assess the safety of combining two medicines, cediranib with paclitaxel, and how well the treatment works in terms of shrinking the cancer and preventing bowel obstruction. Three different medicines are being tested as part of the treatment: Paclitaxel, a standard chemotherapy drug given as a weekly infusion.

DICE - Dual mTorc Inhibition in advanced/recurrent epithelial ovarian, fallopian tube or primary peritoneal cancer (of clear cell, endometrioid and high grade serous type, and carcinosarcoma)

An international multi-centre randomised phase II study to assess the efficacy of TAK228 in combination with intravenous weekly paclitaxel compared with weekly paclitaxel alone in women with advanced/recurrent epithelial ovarian, fallopian tube or primary peritoneal cancer (of clear cell, endometrioid and high grade serous type, and carcinosarcoma).

ICON9: A study evaluating the efficacy of maintenance therapy with olaparib and cediranib or olaparib alone in patients with relapsed platinum-sensitive ovarian cancer

ICON9 is a randomised study and patients will be randomly allocated to receive one or both of the anti-cancer drugs on completion of their chemotherapy (called maintenance treatment). Patients will be in the study for up to 6 years and will continue taking the study tablets until their study doctor thinks they are no longer helping to control the disease. Study tablets may also be discontinued by the study doctor if patients experience side effects that have a negative impact on their quality of life.

MROC: A study looking at using mpMRI scans in staging and treatment decisions for ovarian cancer

Surgery is the usual treatment for ovarian cancer. A CT scan is used to check where the cancer is in the body and helps doctors to know if surgery would be a suitable treatment choice. However, sometimes the CT scan can’t:

OREO: A Phase IIIb, Randomised, Double-blind, Placebo-controlled, Multicentre Study of Olaparib Maintenance Retreatment in Patients with Epithelial Ovarian Cancer Previously Treated With a PARPi and Responding to Repeat Platinum Chemotherapy

The main purpose of this study is to see if Olaparib (study drug) re-treatment is effective in participants with ovarian cancer, who have already been treated with Olaparib or similar drugs. Olaparib is an oral treatment that is taken at home every day. A tablet formulation of olaparib is being tested in this study. It is a new formulation which is more convenient for participants than the approved capsule formulation because fewer tablets of olaparib need to be taken daily than with capsules.

PEACOCC: A phase II study of Pembrolizumab in patients with advanced gynaecological clear cell cancer

All women in the study will receive the study drug, pembrolizumab, for up to 2 years or until their study doctor thinks the study drug is no longer helping to control the cancer or if unacceptable side effects are seen or if the woman wishes to stop treatment. Some women may also be suitable for a possible retreatment period with pembrolizumab for up to 1 year, if the cancer starts growing again.

Phase I clinical trial units

Find out about phase I clinical trials available for women with ovarian cancer.

PROMPT: Phase II trial of maintenance pembrolizumab following weekly paclitaxel for recurrent ovarian, fallopian tube or peritoneal cancer

Women will enter the trial after receiving paclitaxel and will not have received more than three courses of chemotherapy before the paclitaxel. Normally, after receiving paclitaxel, patients are observed without treatment. Maintenance treatment is not a standard treatment for this group of patients. This is why researchers are conducting the PROMPT study, to see if the study drug (pembrolizumab) can slow the growth/return of cancer after treatment with paclitaxel.

PROTECTOR-Preventing ovarian cancer through early excision of tubes and late ovarian removal (PROTECTOR) study

It is now well established that a large proportion of ovarian cancers start in the tube. A number of experts believe that removing the tubes alone would provide some protection from getting ovarian cancer This ‘first stage’ is called risk reducing early salpingectomy (RRES). (Salpingectomy = removal of tubes). This may be particularly helpful for those women who wish to avoid or delay menopause. Women who just have their fallopian tubes removed will need to have a second operation at a later date to remove their ovaries.

RaNGO- Rare Neoplasms of Gynaecological Origin

The purpose of this study is to obtain more information about specific rare gynaecological cancers. Gynaecological oncology doctors have selected approximately 20 gynaecological cancers that are very uncommon (probably between 5 and 50 new cases in the UK per year per rare cancer type). The information from the study will help doctors to better understand how these rare cancers are diagnosed and managed at present so that in the future they can be more confident about what treatments to offer patients.

ROCkeTS: Refining Ovarian Cancer Test Accuracy Scores - a phase III diagnostic test accuracy study

ROCkeTs main study: The aims of the trial are to: Help diagnose ovarian cancer earlier when treatment is likely to work better Help identify which women need further investigations for possible ovarian cancer and reduce unnecessary tests, hospital visits and distress in women who do not have ovarian cancer The researchers hope that the information they collect will help to improve diagnosis for women with ovarian cancer in the future.

SIGNPOST: Systematic Genetic Testing for Personalised Ovarian Cancer Therapy

The trial offers a genetic test to women with certain types of ovarian cancer. This is to detect gene alterations that may be a cause of ovarian cancer. The test will look for alterations in the following genes: BRCA1, BRCA2, RAD51C, RAD51D and BRIP1. At present, testing for changes in the genes BRCA1 and BRCA2 is standard practice. However, testing for the additional genes (RAD51C, RAD51D, BRIP1) is limited to a small number of units.

UKP3BEP A randomised phase 3 trial of accelerated versus standard BEP chemotherapy for patients with intermediate and poor-risk metastatic germ cell tumours.

If you decided to take part in the trial you would be asked to sign a consent form and attend for a screening visit. At this visit you would undergo a series of tests to ensure that you are eligible to take part in the trial.If the results of these assessments are not within the trial ranges, you will not be able to participate in this trial and you will receive standard treatment as per your hospitals standard procedure.

Clinical trials information centre

Results list